Anti-proliferation Effects of RASSF1A on HeLa Cervical Cancer Cells

Cervical cancer is one of the most severe malignant tumors since it is the second largest mortality rate that affect women’s life worldwide (Parkin et al., 2005). There are multiple pathogenesis for cervical cancer, although the primary factor in cervical cancer is infection with human papillomavirus (HPV) (Walboomers et al., 1999). Previously, treatment for cervical cancer mainly focused on radiotherapy together with surgical excision and chemotherapy, however the recurrence rate is still high in many cases of cervical cancer (Jadon et al., 2014). Recent work mainly focused on different expression of oncogenes and tumor suppressor genes (Dammann et al., 2000) in cervical cancer, which are important for the regulation of cell cycle. Therefore, we studied Ras association protein to investigate for a cure of cervical cancer. Ras protein belongs to a class of protein called small GTPase, which is involved in various cell signaling process (Goodsell, 1999). Activation of Ras signaling can result in gene expression that controls the growth, differentiation and survival of cells (Downward, 2003), thus lead to cell proliferation and cancer (Malumbresand Barbacid, 2003). Ras is one of the most common oncogenes (Bos, 1989), which was found in up to 90% cases in several types of cancer as a constitutively active form, including pancreatic